Pathology

Dysplasia to invasive carcinoma takes over 15 years.

􀂄 Macroscopically is divided into papillary, tubular or

nodular. Papillary less invasion to the liver and lymph

nodes.

􀂄 Most carcinomas are adenocarcinomas 80-95%, and

can be papillary, tubular, mucinous or signet cells.

􀂄 Less common types include: anaplasic (2-7%),

squamous cell (1-6%), and adenosquamous (1-4%).

Carcinoid, small-cell, malignant melanoma, lymphoma

and sarcomas are particularly rare.