Pathogenesis

•T-helper cell coordinates the immune response of T & B lymphocytes, monocytes and macrophages

•Both quatitative and qualitative defects lead to both cell mediated and humoral impaired immunity

•HIV is also neurotropic

•Macrophages engulf and plays a role in its dissemination in the CNS

•The host cellular receptor that is recognized by the HIV is CD4 molecule

•This interraction of HIV and CD4 molecule leads to the entry of HIV into the cell